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Depression Help (Home) > Depression Treatment > Use Issues Antidepressants Antidepressants Use IssuesPregnancy use issues with antidepressantsStudies do not agree on the safety of antidepressants during pregnancy or breastfeeding. Most antidepressants (especially selective serotonin reuptake inhibitors [SSRIs]) do not seem to be associated with an increased risk of birth defects or miscarriage, but some may be associated with reduced birth weight. Most antidepressants also seem to be safe during breastfeeding. Though the medication is excreted in breast milk, it seems to cause no harm to the infant. Regardless, the benefits and potential risks of the medication must be weighed for each patient. Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants may be associated with greater risks than selective serotonin reuptake inhibitors. Any woman taking antidepressants who is nursing, pregnant, or plans to become pregnant should discuss the medication with an obstetrician. Child use issues with antidepressants Only the selective serotonin reuptake inhibitor (SSRI) fluoxetine has been approved for use in children, although other SSRIs (and only SSRIs) may also be prescribed for children. However the U.S. Food and Drug Administration (FDA) has advised that antidepressants may increase the potential risk for suicidal thoughts and behavior in children taking them. Close monitoring by a physician of any child on these medications is recommended. Elderly use issues with antidepressants Antidepressants generally work as effectively in elderly patients as in younger adults. Older patients, however, may be more sensitive to side effects and often require lower initial doses. Antidepressants may take longer to take effect for these patients, as well.
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