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Depression Help (Home) > Depression Treatment > Antidepressants Interactions

Antidepressants Interactions

Drug or other interactions with antidepressants

Alcohol

Consumption is generally not recommended while taking any class of antidepressant. Drugs that affect the liver may increase the levels of most antidepressants in the system, which can lead to a potentially dangerous overdose. This is particularly true for tricyclic antidepressants (TCAs). The effectiveness of certain antihypertensive (blood pressure) and anticonvulsant drugs (e.g., valproate, guanethidine, clonidine) may be reduced when taking TCAs.

The heartburn medication cimetidine (Tagamet) can decrease the effect of the selective serotonin reuptake inhibitor (SSRI) paroxetine.

Smoking may reduce the effects of some TCAs. Certain TCAs may increase the sensitivity of the skin to sunlight. It is generally recommended that patients taking these medications wear sunscreen when outdoors. Some medications, such as certain antacids, may reduce the effectiveness of some SSRIs.

Monoamine oxidize inhibitors (MAOIs) can have potentially life-threatening interactions and require dietary and medication restrictions.

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